Easy Access to Cell Surface Oligosaccharide Mimics: Carbohydrate Module Approach

Easy access to modified cyclodextrins by an intramolecular radical approach.

A simple method to modify the primary face of cyclodextrins (CDs) is described. The 6(I)-O-yl radical of α-, β-, and γ-CDs regioselectively abstracts the H5(II), located in the adjacent D-glucose unit, by an intramolecular 1,8-hydrogen-atom-transfer reaction through a geometrically restricted nine-membered transition state to give a stable 1,3,5-trioxocane ring. The reaction has been extended t...

Easy Access to Modified Cyclodextrins via an Intramolecular Radical Approach

A simple methodology to modify the primary face of cyclodextrins (CDs) is described. The 6-O-yl radical of α-, β-, and γCD abstracts regioselectively the H5, located in the adjacent Dglucose unit, by an intramolecular 1,8-hydrogen atom transfer reaction through a geometrically restricted nine-membered transition state to give a stable 1,3,5-trioxocane ring. The reaction has been extended to 1,4...

Easy access to antifungal agents.

Vulvovaginal candidiasis is a common problem; at one time or another most women experience at least one episode of this bothersome condition. For the past several years, the pharmaceutical industry has convinced women that this condition is easily treated and that they should recognize the symptoms of vulvovaginal candidiasis. Thus women have had access to a variety of intravaginal antifungal a...

Miniaturization of microwave-assisted carbohydrate functionalization to create oligosaccharide microarrays.

Easy access to stable pentavalent uranyl complexes.

Reaction of UO2I2(THF)3 with 1 molar equivalent of KC5R5 (R = H, Me) in pyridine led to the uranyl(V) compound {[UO2(Py)5][KI2(Py)2]}(infinity), which is an infinite 1D polymer in its crystalline form; the UO2X(THF)n (X = I, OSO2CF3) complexes were obtained by reduction of their U(VI) parents with TlC5H5 or KC5R5 in THF.